Donald E. Ingber, MD, PhD
Founding Director, Wyss Institute for Biologically Inspired Engineering at Harvard University
Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital
Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences
Dr. Donald Ingber is a founder of the emerging field of biologically inspired engineering, and at the Wyss Institute, he oversees a multifaceted effort to identify the mechanisms that living organisms use to self-assemble from molecules and cells, and to apply these design principles to develop advanced materials and devices for healthcare and to improve sustainability. Dr.Ingber has made major contributions to mechanobiology, tissue engineering, tumor angiogenesis, systems biology, and nanobiotechnology. Dr. Ingber has authored more than 375 publications and 85 patents, and has received numerous honors including the Holst Medal, Pritzker Award from the Biomedical Engineering Society, Rous-Whipple Award from the American Society for Investigative Pathology, Lifetime Achievement Award from the Society of In Vitro Biology, and the Department of Defense Breast Cancer Innovator Award.
Human Organs on Chips as Replacements for Animal Testing
In this presentation, Dr. Ingber will describe hiswork focused on the engineering of human 'Organs-on-Chips': microfluidic devices lined by living human cells created with microchip fabrication techniques that recapitulate organ-level functions as a way to replace animal testing for drug development and to create in vitro human disease models. These biomimetic devices provide a window on human physiology as they enable real-time, high-resolution microscopic imaging as well as analysis of biochemical, genetic and metabolic activities of living cells when they are positioned within the context of functional tissue and organ units. Dr. Ingber will review recent advances he and his team have made in development of multiple organ chips, including human lung, gut, kidney and bone marrow chips, as well as on-chip models of human diseases, including pulmonary edema and inflammatory bowel disease. In addition, he will describe his ongoing efforts to develop more than 10 different organ chips, to integrate them into a 'human body on chips', and to engineer an automated instrument for real-time analysis of cellular responses to pharmaceuticals, toxins and other chemicals.
Francis Collins, MD, PhD
Director, National Institutes of Health (NIH)
Francis S. Collins, M.D., Ph.D. is the Director of the National Institutes of Health (NIH). In that role he oversees the work of the largest supporter of biomedical research in the world, spanning the spectrum from basic to clinical research.Dr. Collins is a physician-geneticist noted for his landmark discoveries of disease genes and his leadership of the international Human Genome Project, which culminated in April 2003 with the completion of a finished sequence of the human DNA instruction book. He served as director of the National Human Genome Research Institute at the NIH from 1993-2008.Before coming to the NIH, Dr. Collins was a Howard Hughes Medical Institute investigator at the University of Michigan. He is an elected member of the Institute of Medicine and the National Academy of Sciences, was awarded the Presidential Medal of Freedom in November 2007, and received the National Medal of Science in 2009.
Author, journalist and authority on global health issues
Laurie Garrett is one of America’s leading commentators on global health issues. She is the only person to win the three P’s of journalism: The Pulitzer Prize, the Peabody Award, and the Polk Award. She is a Senior Fellow for Global Health at the Council on Foreign Relations, and is the bestselling author of The Coming Plague and Betrayal of Trust. She has written for Foreign Affairs, Esquire, and The Washington Post, and appears frequently on television shows, such as Nightline, Charlie Rose and Oprah. Garrett also served as a script consultant to Contagion, the film directed by Steven Soderbergh and starring Matt Damon. Garrett is a former president and now a member of the National Association of Science Writers, and has been awarded three honorary PhDs. Garrett’s long-awaited third book, now in stores, is called I HEARD THE SIRENS SCREAM: How Americans Responded to the 9/11 and Anthrax Attacks.
Betrayal of Trust: Critical Issues in Global Healthcare
Based on her international travels to report on and research healthcare, Laurie Garrett will deliver apresentation that uncovers the reality of healthcare in the United States, Europe, Russia and Africa — providing a new understanding of both the challenges and the opportunities of delivering quality healthcare to the global village.